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Pharmaceutical drug interactions with CBD

First and foremost, we always recommend that you consult a health professional before taking CBD, especially if you are on other medications.

No serious drug interactions have been reported, however, CBD does inhibit the activity of cytochrome P450, a family of liver enzymes...

 

What are cytochrome P450 enzymes?

These enzymes help metabolize (break down) most of the drugs we consume, including THC. This is why CBD is known to counteract the effects of THC.

The bottom line is that: As CBD could inhibit the effectiveness of the P450 enzymes, your body does not break down certain drugs as effectively - over time they could accumulate in your body.

Here is a list of drugs that this enzyme metabolizes

 

Another consideration is taking CBD with a P450 inducers or inhibitors

Reports have shown that when CBD is taken with an inducer such as carbamazepine, rifampicin, alcohol (chronic), phenytoin, griseofulvin, phenobarbitol and sulphonylureas, CBD may increase the activity of these drugs, which could result in increased levels in your blood.

Similarly, if you are currently taking any P450 inhibitors (such as cimetidine, ketoconazole or erythromycin), then it is recommended that you do not take CBD. Taking both a P450 inhibitor and inducer together could lead to unpredictable drug interactions and may be dangerous.

As such, it is important to discuss any potential interactions with your doctor before taking CBD alongside other medications.

Additional reading on the topic can be found here:

https://www.projectcbd.org/article/cbd-drug-interactions-role-cytochrome-p450

https://www.researchgate.net/publication/22305086_Cannabidinol_-_antiepileptic_drug_comparisons_and_interactions_in_experimentally_induced_seizures_in_rats_J_Pharmacol_Exp_Ther

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