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The Known Side Effects of Cannabidiol

The Known Side Effects of Cannabidiol

What do people need to know about the side effects of cannabidiol before turning to it as a viable treatment? Find out the possible risk factors at Sol CBD.

There are two sides to nearly every modern medicine, both within the traditional and alternative sectors. When a patient takes medication for its positive characteristics which target a specific health issue or ailment, they should also acknowledge that many treatments have unwanted characteristics that go hand-in-hand with their benefits. The side-effects can often lead people to take even more medication to handle them, and still other people choose to seek alternative medicines which typically have less severe or fewer unwanted effects.

This has led many people to turn towards cannabidiol (CBD) as an alternative therapy considering its wide ranging medical benefits but low negative reactions. Does this mean that CBD has no side-effects? What do people need to understand about CBD’s possible risk factors prior to turning to it as a viable treatment?

The good news is that the vast majority of research into the subject has found that CBD treatments show little to no risk of side-effects; even in higher doses of up to 1,500 mg a day. Unlike its sister substance, THC, CBD doesn’t have any psychoactive effects, nor does it seem to alter heart rate, appetite, blood pressure or body temperature.

However, with all this in mind there has been some evidence to suggest that it can interact with some pharmaceuticals, and cause decreased activity of p-glycoprotien. Cannabidiol has been proven to interact with cytochrome P450 enzymes, which are located within your liver.

What all this scientific lingo is saying, is that CBD can inhibit or otherwise affect the movement of or absorption of pharmaceuticals within the body, especially in higher doses. Especially in the case of its interactions with your liver enzymes, CBD can affect the way medication is metabolized through the liver. That being said, this is specifically the side-effect being sought after by some people as in one example, CBD will inhibit the negative effects of THC. It is also interesting to note that everyday foods also can have the same effects on the liver, including grapefruit.

Other studies have found that CBD can in some cases increase the sensation of dry-mouth. This is likely caused by the way cannabidiol interacts directly with the endocannabinoid system, specifically CB-1 and CB-2 receptors. These receptors are present within the glands responsible for saliva production, and CBD can therefore alter saliva production and cause the sensation of dry-mouth.

In still another study, increased tremors and muscular movements were recorded for Parkinson’s patients on extremely high doses of CBD. Strangely enough CBD treatment has been shown to be extremely effective for many people suffering from Parkinson’s Disease and therefore the negative responses may be associated with a specific dosage. In past studies of CBD’s effect on animals, where monkeys were given extremely high doses of CBD, tremors and cardiac failure were recorded. Those animals who were subsequently given lower doses, recovered completely within a few days.

These studies have never been replicated in humans, and as noted before, CBD has never shown any strongly adverse reactions even in higher doses (up to 1500mg a day in one often cited study) for humans. Obviously more research in this area is needed to better understand the nuances of CBD’s dosage and its effect on Parkinson’s and other health issues.

The inhibitory effect that CBD treatment has on the human immune system is also a double edged sword. In some cases, this may be specifically why someone chooses to use CBD, while in others it can be considered a true side effect. For instance, the specific manner in which CBD inhibits the human immune system also may increase some disease progression, HIV-infection, as well as metastasization of tumors. In this case though, there is also a suggestion that it is the dosage which alters the effect on the body, as lower doses do not tend to show these same effects.

In animal studies, high CBD doses have affected fertilization capacity. This has yet to be demonstrated in a human clinical trial, but at least in the study of sea-urchins it has been found to reduce the fertilization capacity of sperm. For women who are pregnant or breastfeeding, there is currently little to no research available on the possible side-effects of using CBD. Therefore, until there is a solid understanding of CBD during these times, it is recommended that pregnant and nursing women avoid using CBD treatments.

The fact that CBD has such low risk of side-effects is exactly why many people are turning towards it has an alternative treatment. Typically, people using CBD as an alternative treatment have already weaned themselves off of most pharmaceuticals and therefore CBD will have no negative interactions. Finally, the few side-effects which have been recorded are limited and rare; typically, only present with higher dosages.

Resources

http://www.treatmentactiongroup.org/tagline/2000/july/whats-about-p-glycoprotein

https://elixinol.com/blog/known-and-potential-side-effects-of-cannabidiol-cbd/

http://www.webmd.com/vitamins-supplements/ingredientmono-1439-cannabidiol.aspx?activeingredientid=1439&activeingredientname=cannabidiol

http://www.medicinalgenomics.com/wp-content/uploads/2013/01/Bergamaschi_2011.pdf

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